Aquaporin-4 Antibodies (Nmo-IgG), Serum

You should get a serum aquaporin-4 antibody (NMO-IgG) test if you have sudden vision loss or eye pain, limb weakness, numbness, or bladder problems, or unexplained persistent hiccups or vomiting. It is also recommended when multiple sclerosis is suspected, to rule out NMOSD, and ideally before starting immunotherapy for accurate results.

No special preparation or fasting is required for a serum aquaporin-4 antibody test. Inform your doctor about any steroids, immunosuppressants, plasma exchange, or IVIG treatment, as these can lower antibody levels and cause false-negative results. Ideally, give your sample before starting treatment. Follow your lab's specific instructions.

No, fasting is not required for a serum aquaporin-4 antibody (NMO-IgG) test. You can eat and drink normally before giving your sample. Inform your doctor about any steroids, immunotherapy, plasma exchange, or IVIG, as these can affect results. Ideally, the test should be done before treatment begins.