Aquaporin-4 Antibodies (Nmo-IgG), CSF

A CSF aquaporin-4 antibody (NMO-IgG) test is advised by a neurologist if you have sudden vision loss or eye pain, weakness, numbness, or bladder problems suggesting spinal cord inflammation, or unexplained persistent hiccups or vomiting. It is also used when serum testing is negative but NMOSD is still suspected, or to rule out NMOSD before treating multiple sclerosis.

A CSF aquaporin-4 antibody test requires a lumbar puncture (spinal tap). Inform your doctor about any blood thinners, bleeding disorders, allergies, or pregnancy, and about steroids, immunotherapy, or plasma exchange, as these can lower antibody levels. Fasting is usually not required. Empty your bladder beforehand, and plan to rest after the procedure.

No, fasting is usually not required for a CSF aquaporin-4 antibody (NMO-IgG) test. You can eat and drink normally unless your doctor advises otherwise, for example if sedation is planned for the lumbar puncture. Inform your doctor about any blood thinners or bleeding disorders, and follow the hospital’s specific instructions.