Simira Diagnostics
Immunology

Anca-C (Pr3)

  • Report in 5 hrs
  • Serum sample

Price

₹2,000

  • Report in 5 hrs
  • Free home sample collection
  • ₹200 off at checkout
  • NABL certified lab

or call 77900 98009

Anca-C (Pr3)

₹2,000

About this test

The ANCA-C (PR3) test detects antibodies against proteinase 3 (PR3), an enzyme in neutrophils. It is a key marker of ANCA-associated vasculitis.

A normal result is negative, below the lab’s cut-off value.

A positive PR3-ANCA strongly suggests granulomatosis with polyangiitis (GPA), formerly Wegener’s granulomatosis, which affects the sinuses, nose, lungs, and kidneys. Symptoms include chronic sinusitis, nosebleeds, coughing up blood, lung nodules, and rapidly progressive kidney failure.

It helps confirm diagnosis and monitor disease activity, as rising levels may signal relapse.

Questions about this test

When should I get the Anca-C (Pr3) test?

You should get an ANCA-C (PR3) test if you have chronic sinusitis, crusting or bleeding from the nose, ear problems, coughing up blood, lung nodules, blood in the urine, or rapidly worsening kidney function. It is also recommended for suspected granulomatosis with polyangiitis, a positive c-ANCA on IFA, and monitoring treatment.

How should I prepare for the Anca-C (Pr3) test?

No special preparation or fasting is required for an ANCA-C (PR3) test. Inform your doctor about any steroids, immunosuppressants, rituximab, or plasma exchange, as these can lower antibody levels and affect results. Also mention any cocaine use or medicines like hydralazine or propylthiouracil, which can cause positive ANCA results.

Do I require fasting for the Anca-C (Pr3) test?

No, fasting is not required for an ANCA-C (PR3) test. You can eat and drink normally before giving your sample, and the test can be done at any time of day. Inform your doctor about any immunosuppressive treatment, as it may lower antibody levels and affect the results.

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