Simira Diagnostics
Molecular

Alpha Thalassemia deletion/ duplication analysis by MLPA

  • Report in 1 hr
  • Serum sample

Price

₹10,000

  • Report in 1 hr
  • Free home sample collection
  • ₹200 off at checkout
  • NABL certified lab

or call 77900 98009

Alpha Thalassemia deletion/ duplication analysis by MLPA

₹10,000

About this test

Alpha thalassemia MLPA detects deletions and duplications in the HBA1 and HBA2 genes and their regulatory region, including common and rare deletions that routine tests may miss.

Results indicate the number of affected genes:

  • One gene deleted: silent carrier
  • Two genes: alpha thalassemia trait, with mild anemia
  • Three genes: HbH disease
  • Four genes: Hb Bart’s hydrops fetalis, which is usually fatal before birth

It also detects alpha gene duplications, which can worsen beta thalassemia. It guides carrier screening, couple counseling, and prenatal diagnosis. Point mutations need sequencing.

Questions about this test

When should I get the Alpha Thalassemia deletion/ duplication analysis by MLPA test?

You should get an alpha thalassemia MLPA test if you have low MCV or MCH (small red cells) with normal iron levels and normal HbA2, or suspected HbH disease. It is also recommended for couples planning pregnancy with a family history of thalassemia, when both partners are carriers, for prenatal diagnosis, and for unexplained hydrops in pregnancy.

How should I prepare for the Alpha Thalassemia deletion/ duplication analysis by MLPA test?

No special preparation or fasting is required for an alpha thalassemia MLPA test, as it analyzes DNA from a blood sample. Inform your doctor about any recent blood transfusion. Bring your previous CBC, Hb electrophoresis/HPLC, and iron study reports, along with your partner’s reports if available. Genetic counseling is recommended before and after testing.

Do I require fasting for the Alpha Thalassemia deletion/ duplication analysis by MLPA test?

No, fasting is not required for an alpha thalassemia MLPA test. You can eat and drink normally before giving your sample, because the test analyzes your DNA, which is not affected by food or the time of day. Inform your doctor about any recent blood transfusion.

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