Simira Diagnostics
Immunology

ACTIVE B12 LEVEL

  • Report in 5 hrs
  • Serum sample

Price

₹2,000

  • Report in 5 hrs
  • Free home sample collection
  • ₹200 off at checkout
  • NABL certified lab

or call 77900 98009

ACTIVE B12 LEVEL

₹2,000

About this test

The Active B12 test measures holotranscobalamin (holoTC), the form of vitamin B12 that body cells can actually use. It is considered an early and more reliable marker of B12 deficiency than total serum B12.

A typical normal Active B12 level is above 50 pmol/L, though cut-offs vary by lab. Low Active B12 (below about 35 pmol/L) suggests deficiency even when total B12 appears normal.

It is especially useful for vegetarians, pregnant women, the elderly, and people on metformin. Early detection helps prevent anemia and permanent nerve damage.

Questions about this test

When should I get the ACTIVE B12 LEVEL test?

You should get an Active B12 (holotranscobalamin) test if you have early signs of B12 deficiency, such as fatigue, tingling, numbness, memory problems, or a sore tongue, especially when total B12 appears normal or borderline. It is recommended for vegetarians, pregnant women, the elderly, and people taking metformin or antacids long-term.

How should I prepare for the ACTIVE B12 LEVEL test?

Fasting for 8–12 hours is usually recommended before an Active B12 (holotranscobalamin) test, and you may drink water during this time. Inform your doctor about any B12, B-complex, or multivitamin supplements or B12 injections, as recent intake can affect results. Also mention medicines like metformin or antacids. Follow your lab's instructions.

Do I require fasting for the ACTIVE B12 LEVEL test?

Yes, fasting is usually recommended for an Active B12 (holotranscobalamin) test. You should fast for 8–12 hours before giving your sample, though drinking water is allowed. Inform your doctor about any B12 supplements or injections you take, as they can raise your levels and affect the accuracy of the results.

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